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Recent news

OPIS co-organising national conference on palliative care & pain relief in Burkina Faso,
2-3 December 2019

6 October 2019: OPIS is pleased to announce that a national conference to promote palliative care and pain relief in Burkina Faso is now confirmed for 2-3 December 2019. The conference is being organised by our partner Hospice Burkina together with the Ministry of Health of Burkina Faso and OPIS. We are providing most of the funding for the conference, thanks to the successful crowdfunding campaign we carried out this year with the support of so many generous donors, and were involved in presenting the case to the Health Minister, who will be speaking at the conference, of the urgency of establishing a national palliative care program. Further details and program will be made available soon. Please also check our Facebook page.

New book ”Seres que sienten" ("Sentient beings”) by OPIS Associate Manu Herrán

23 May 2019: OPIS Associate Manu Herrán has just published a new book about sentience titled ”Seres que sienten" ("Sentient beings”) in which he exposes the main arguments and evidence demonstrating sentience in animals, and therefore their moral relevance. He uses these same arguments to defend the idea that we must take into account the possibility of the existence of sentience in machines, software simulations and manipulated biological substrates. An English version of the book is expected to be released in the next months. The Spanish version can be bought at https://www.amazon.es/dp/1096836726Benefits from the book will go to the animal shelter La Casita de Lluvia, managed by Adriana Caiaffa, who also created the book's watercolours.

"The other opioid crisis" by Niki Seth-Smith, New Humanist, 10 December 2018


The danger is that the American tragedy will further dampen political will. The dying and seriously ill are not a vocal demographic. They are often tucked away out of sight, and practitioners in the medical field are not always the best people to tell a story. However, a new “think-and-do-tank” is determined to give voice to those around the world experiencing severe pain. The Organisation for the Prevention of Intense Suffering (OPIS) was set up in 2016 by Jonathan Leighton, a former research scientist turned writer and author of The Battle for Compassion: Ethics in an Apathetic Universe. Access to morphine as a human right is a top campaign for OPIS. “Many who need morphine are terminally ill, they may have only weeks or months to live, and it’s essential that they can live as comfortably as possible,” Leighton says. “The concerns are completely disproportionate compared to the actual primary issue at hand.”

The primary issue for OPIS is the ethical imperative to reduce suffering. Linked to the effective altruism movement, they choose causes that are most likely to produce the largest impact, determined by what Leighton calls “a clear underlying philosophy which is suffering-focused”. It’s challenging to fully empathise with others in extreme pain, especially when so many causes constantly demand our attention. According to OPIS, a morally rational approach to policy would attempt to weigh each subjective experience. “I’d like to translate that understanding into social change,” Leighton says. “Ideally systemic social change.”

OPIS and Hospice Burkina collaborating to promote access to morphine and palliative care in Burkina Faso

Jonathan Leighton, Executive Director of OPIS, met at the end of September 2018 in Belgium with Dr. Martin Lankoande, an anaesthesiologist who recently established Hospice Burkina, the palliative care association of Burkina Faso. Dr. Lankoande has taken the initiative to ensure the incorporation of palliative care into the basic health plan and the availability of oral morphine to all those in need. Currently, very few of the many thousands of patients in severe pain every year in Burkina are able to obtain morphine to alleviate their pain. OPIS has been collaborating closely with Hospice Burkina since a few months ago. The next step is a national conference on the subject early next year that will promote concrete solutions to all the existing obstacles that have been identified. Within a few years, we hope that Burkina Faso will become a new west African success story in addressing one of the major sources of intense human suffering. More info here.

This document offers an analysis of how donations to support these activities might compare in effectiveness with other effective causes.

OPIS advocates at UN Human Rights Council for access to morphine

Millions of children and adults in low- and middle- income countries, inflicted with terminal or life-threatening illnesses and suffering from severe physical pain, are unable to access morphine, an effective treatment that is easy and inexpensive to produce. As a call to action to address this devastating but solvable situation, on 14 March 2018 OPIS and International Doctors for Healthier Drug Policies (IDHDP) held an official side event with expert panellists during the 37th session of the UN Human Rights Council in Geneva, titled “Ending the Agony: Access to Morphine as an Ethical and Human Rights Imperative”. More info here.

On 18 May 2018, OPIS and IDHDP submitted a joint contribution to the OHCHR report on the implementation of the UNGASS joint commitment to effectively addressing and countering the world drug problem with regard to human rights.

Read also:

Why Access to Morphine is a Human Right

About OPIS

The Organisation for the Prevention of Intense Suffering (OPIS) is a think-and-do tank working to design and promote the compassionate society of the future. OPIS’s vision is a world that eliminates the preventable suffering of all sentient beings, both humans and non-humans, and that meets the needs of all through rational, evidence-based decision-making. OPIS engages in research, education, advocacy and creative communications, promoting both solutions to specific causes of intense suffering and ethical systemic change. OPIS was founded in 2016 as a Swiss non-profit association and is headquartered in Geneva. Follow us on Facebook and on Twitter.


      À propos d'OPIS       Über OPIS       Sobre OPIS     

A different kind of think-and-do tank

OPIS strives to make a difference in preventing suffering by developing projects that explore new terrain and present the opportunity to have real impact, complementing the work of existing organisations. We identify with the effective altruism (EA) movement and the importance of quantifying and optimising impact, while also experimenting with new, creative approaches that we estimate can make an effective contribution. These include new ways of value-spreading and raising awareness through advocacy, education, films and campaigns; collaboration on developing new blueprints for society; and concrete, evidence-based recommendations on how both individuals and institutions can make a difference.

Our structure is flexible and unbureaucratic. We will be looking to expand our activities by collaborating with other like-minded organisations and social change agents around the world.


Why "intense" suffering?

Suffering is rarely if ever a good thing in itself, even though it can lead to personal growth and sometimes allow us to appreciate happiness that follows it even more. But the intense suffering of torture or certain chronic diseases can make life literally unbearable. This suffering, which cries out to be relieved, is on a whole different level, and it makes minor forms of suffering pale in comparison. There is nothing else that has greater urgency than preventing or relieving the intense suffering of sentient beings. Because so much of it is preventable, and in many cases even caused by human beings, it is essential that we explicitly recognise it as our highest priority as a society. OPIS supports all efforts to prevent or reduce any kind of suffering, but the focus on "intense" suffering ensures that we do not lose sight of our most urgent priorities.

Human and non-human animals

Does the suffering of non-human animals matter as much as human suffering, or are "some animals more equal than others”? OPIS takes the rational ethical stance that suffering matters for its own sake, regardless of who experiences it, and that equal degrees of suffering matter equally. Although we naturally have the strongest feelings for those closest to us and value their lives most, as an organisation OPIS cares as much about any sentient being, human or non-human, that is suffering intensely. The sheer number of animals suffering on this planet, including the huge numbers kept in horrific conditions on factory farms or otherwise treated with cruelty, means that animal suffering is the area with by far the greatest potential for harm reduction, and it is also the area where the most impact can be achieved for a given amount of resources. But OPIS is not only an animal rights organisation. We think that a holistic approach to preventing suffering on our planet requires that we also aim to relieve our own suffering. We believe that this approach provides a strong basis for new frameworks for society. By drawing a parallel between human and non-human suffering without ignoring the former, we hope to build greater awareness of the latter as well.

The 20-minute film The Battle for Compassion, based on the book of the same name, captures the thinking and philosophy of OPIS.

And in case you were wondering: the OPIS logo is based on Hathor, the Egyptian goddess of love and joy, who wore a sun disc with cow horns. Love and joy are emotions that are instrumental in reducing suffering and are key elements of the world we strive for. The horns also reflect the significance of animal suffering.



OPIS’s overall work is aimed at promoting a global society that eliminates preventable suffering. Our projects support this aim at different levels:
  • Defining a holistic, rational ethical framework that reconciles different perspectives on ethics.
  • Providing an overview of world suffering and the risks of future suffering.
  • Advocacy on specific sources of intense suffering. OPIS has taken on the issue of the lack of access to morphine and other therapeutic opioids in much of the world, a cause of widespread intense human suffering.
  • Education to promote empathetic perspective-taking and compassion towards all sentient beings.
  • Designing new blueprints for a compassionate society in which all decision-making is aimed at preventing suffering, and a strategy for achieving greater consensus around this goal. OPIS is planning expert workshops on this theme to share expertise and promote collaboration.
  • Developing creative communication tools, including films and campaigns, to promote compassion and actions towards specific goals.
The following projects are underway or in planning. If you are interested in contributing or collaborating, we welcome you to contact us.
Ethical framework

The importance of preventing intense suffering is clear, but there is a need for a more comprehensive ethical framework that addresses apparent conflicts and shortcomings of existing ethical theories, and that can help guide decision-making. For example, how can we trade off intensity of suffering vs number of individuals? How do we value happiness compared to suffering? Are the current metrics used in health economics ethically relevant? Work is underway to develop and promote a more holistic ethical framework that addresses such questions and acknowledges the role and limits of both rationality and intuition. More information is contained in the ethics & values section.


One of the main cause areas we have been focusing on is the tragic lack of access to morphine and similar opioids for the treatment of moderate to severe pain in low- and middle-income countries. On 14 March 2018 we held an official side event at the Human Rights Council in Geneva titled "Ending the Agony: Access to Morphine as an Ethical and Human Rights Imperative", in partnership with IDHDP. We also issued a widely distributed summary guide to the issue being used as an advocacy tool. We are currently collaborating with country palliative care associations to promote access and change regulations. We will also be conducting campaigns aimed at raising awareness of human and non-human suffering and pressing for specific actions, in collaboration with other like-minded organisations.

Toolkit for teaching compassion in schools

A crucial element of reducing suffering in the future is to develop a more compassionate global culture. One of the key approaches to achieving this is to bring up a new generation of young people whose empathy for other sentient beings and capacity for perspective-taking have been nurtured, and who have learned about the importance of reducing suffering - including their own - through education in compassion and self-compassion. To this end, a toolkit for educators is being prepared that will bring together some of the most effective tools and approaches in one place, and provide guidance on how to introduce compassion training to schools. The toolkit will be translated and widely communicated. In the meantime, we have a list of existing resources for teaching compassion.

Policy recommendations and designing new blueprints
We are developing white papers and recommendations for translating compassionate ethics into policy, both for specific suffering-related issues (e.g. collaboration with ATIP on guidelines for opioid pain medication) and for more general, structural causes of suffering in society. We are planning soon to organise expert workshops on designing blueprints for a more compassionate future, incorporating some of the most important and often neglected principles of human systems and psychology.
Quantify and visually display worldwide suffering

A project is underway to collect data on suffering in the world and represent it in a visually powerful way. The purpose is to create a rough numerical and visual overview of the phenomenon of suffering that can be used to help evaluate and adjust our priorities as a society. Data are being gathered on sources of suffering, numbers of individuals affected and estimated intensities. Both human and animal suffering are being included and will be both treated separately and compared. More background on this project is contained in this document.

Short films and full-length documentaries
One of the most effective tools for raising awareness of suffering and promoting compassion is the production of videos and films. The film "Earthlings", for example, had a dramatic effect in raising awareness of the widespread intense suffering of animals at the hands of humans. OPIS plans to create a series of short videos to address specific aspects of human and non-human suffering, and produce a major full-length documentary film that will reach many people worldwide with a message of action-oriented compassion.


Management and operations

Jonathan Leighton
Executive Director

Jonathan founded OPIS in 2016 and brings a mixture of rationality and creativity to his passion of helping to reduce suffering in the world. Jonathan obtained a PhD in molecular biology after studying at Harvard and the University of Basel, and spent several years in industry before turning to writing and public speaking on ethics and compassion. He is the author of The Battle for Compassion: Ethics in an Apathetic Universe (New York: Algora Publishing, 2011), which offers a sweeping overview of our situation as a species and methodically addresses the question “What matters?” He also produced a short film to communicate some of the key ideas. He is currently working on a new book that develops a more holistic approach to ethics. @JonLeighton1


Jean-Christophe Lurenbaum

Jean-Christophe decided at an early age to dedicate his life to organising the creation of greater happiness in the world. With this aim, he first trained as an economist and became a key strategist in charge of major projects at France’s largest public corporation, La Poste. He wrote Naître est-il dans l'intérêt de l'enfant? Idéologie de reproduction versus non-souffrance (2011), the result of a decades-long historical exploration of the conflict between the ethic of non-suffering and the ideology of reproduction. In 2013 he co-founded the Algosphere Alliance, a network and direct democracy for the alleviation of suffering.

Manu Herrán

Manu is a passionate thinker and communicator dedicated to finding ways to prevent suffering. A computer engineer, he has created AI and life simulations, and he is the author of fiction stories and about 100 essays investigating issues related to evolution, cooperation, conscience, sentience, intelligence, death, ethics and other themes. He is the founder of the REDcientifica magazine and author of the philosophical book Arena Sensible (in Spanish; "Sensitive Sand"). Manu is a regular public speaker on animal suffering and also on the neglected possibility of suffering in inorganic substrates. @mherran

Robert Daoust

Robert is one of the world’s experts on suffering and has long advocated for a discipline dedicated to its study, for which he created the term “algonomy”. Over the years he has systematically compiled a wealth of references and accumulated extensive knowledge on the topic of suffering, for which he was a main contributor to the Wikipedia entry. In 2013 he co-founded the Algosphere Alliance, a network and global democracy for the alleviation of suffering.

Sorin Ionescu

Sorin holds a Master in Software Engineering from Concordia University in Montreal and has a background in artificial intelligence. A social activist, he believes that love is the most powerful engine in the pursuit of alleviating suffering, and he strives to create bridges and partnerships between social change groups with diverse approaches. Sorin is working with Vegan Option Canada to add vegan options to the menus of all public institutions in Canada, and is an active member of Regard Animal, spreading awareness of speciesism and animal rights through art and social union. He is also on the Communications Committee of the Algosphere Alliance.

Alyssa Berris

Alyssa holds a master’s degree in sociology and is a co-founder of Vegan Option Canada and the Gatineau Vegetarian Association. A social activist for the recognition of vegan rights, for the fight against climate change and the improvement in the wellbeing of animals, Alyssa is involved in the collective effort for a healthy, sustainable and socially responsible global ecological transition. She is also a member of the Algosphere Alliance.

Justin Kwong

Justin is currently studying health science at Boston University. He is an active member of the Boston effective altruism community and was a lead organiser of the EAGxBoston 2019 conference. After completing his undergraduate degree, he hopes to work on the prevention and alleviation of extreme suffering in nonhuman animals. Justin is working with OPIS to create a visualisation of world suffering data. He is also an ally of the Algosphere.

Board of Directors

Jonathan Leighton

See bio above


Jean-Christophe Lurenbaum

See bio above

Jonas Vollmer

Jonas is Executive Director of the Effective Altruism Foundation and manages and coordinates EAF's activities. He studied medicine and economics with a focus on health and development economics, during which time he acquired expertise central to charity evaluation. He previously served on the boards of several charities. His career choice, motivated by effective altruism, was covered in major Swiss media outlets. @Jonas_Vollmer

Advisory Board

David Pearce

David is an influential philosopher who defends a form of negative utilitarianism and advocates the abolition of suffering in all sentient life, an argument he detailed in The Hedonistic Imperative, a book-length web-based manifesto from 1995. A committed vegan and an inspiration to countless philosophers and activists for his compassion and intellect, David is also a leading figure in the transhumanist movement and co-founder of Humanity+. He envisions a world where science and technology are used to replace suffering with gradients of bliss. @webmasterdave

Samah Atout

Samah is a humanist, career diplomat and political advisor dedicated to building a more peaceful civil society. She held key diplomatic positions representing Palestine at the UN in Geneva and at the EU in Brussels. She has worked as a lobbyist to European Union institutions and as a political advisor to the President of the UN General Assembly, and served with the UN in Libya to work with the General National Congress President on institutional building. Samah has also founded two key social projects in the West Bank, Project Hope and Zajel, and is a partner at a private investment boutique in Geneva. She strongly believes that change towards a more peaceful world is possible through grassroots work and diplomacy.

Sandeep Sibal

Sandeep is CEO of Fourth Frontier, which builds wireless products for assessing health and enhancing wellbeing using novel biosensors and advanced algorithms. The technology allows the objective measurement of stress and pain and its management, and is applicable to both humans and other mammals. Previous positions included VP Business Development for India and South Asia at Qualcomm and Founder & CTO of hi-tech startup Kirusa. He is also a co-inventor of 25 US patents. Sandeep has a keen interest in the prevention of suffering of all sentient beings. He is a patron of Amnesty International, PETA and Humane Society International, and has participated in the India Against Corruption movement. He also serves on the board of GiveIndia, one of India’s leading philanthropic exchanges. @sandeepsibal

Andrés Gómez Emilsson

Andrés is a consciousness researcher at the Qualia Research Institute. He holds degrees in Artificial Intelligence and Cognitive Science and in Computational Psychology from Stanford University, where he also co-founded the Stanford Transhumanist Association. Andrés grew up in Mexico and represented his country in international math and science Olympiads. He has a wide range of interests and experience at the intersection of mathematics, philosophy and psychology. He is currently researching the mathematical and neurological correlates of hedonic states including bliss, with a deep passion for finding ways to abolish the hell of extreme suffering. He writes a fascinating, eclectic blog called Qualia Computing. @algekalipso

Tobias Leenaert

Tobias is an international public speaker and writes a popular blog called The Vegan Strategist. Together with Melanie Joy he co-founded and co-directs the Center for Effective Vegan Advocacy. He is known for his pragmatic, non-confrontational approach to encouraging people to adopt a cruelty-free vegan lifestyle. Tobias was also the founder of the Belgian non-profit vegetarian organisation EVA, and was elected a Fellow of Ashoka, an international organisation supporting high impact social entrepreneurs. @TobiasLeenaert

Nell Watson

Nell is an engineer, entrepreneur and futurist thinker who grew up in Northern Ireland. Nell lectures globally on Machine Intelligence, AI philosophy, Human-Machine relations and the Future of Human Society. She is also Co-Founder of OpenEth.org, an ‘ethical explication engine’ that aims to crowdsource ethical heuristics for autonomous systems, and she serves on the Faculty of AI & Robotics at Singularity University. @NellWatson

Oscar Horta

Oscar teaches philosophy at the University of Santiago de Compostela, Spain. He has been involved in vegan and anti-speciesist activism since the mid-1990’s and is a member of the organisation Animal Ethics. His main fields of work are speciesism and the moral consideration of animals living in the wild. He has many publications addressing these issues and has given talks about them in more than 15 countries.

Jamie Catto

Jamie is a creative catalyst – a musician, filmmaker, author and coach who also runs workshops on personal development. Jamie was a founding member of the British supergroup Faithless and one half of the film-and-music project One Giant Leap. Jamie has become a strong opponent of factory farming and the suffering it causes to animals, viewing it as one of the greatest moral issues of our time, and actively supports creative projects to help end it. @JamieCatto

Lucius Caviola

Lucius is a co-founder and current advisor to the Effective Altruism Foundation. He studied psychology at the Universities of Basel and Oxford and is carrying out research in cognitive and moral psychology at the Department for Experimental Psychology and at the Uehiro Centre for Practical Ethics at the University of Oxford. He previously worked as an IT entrepreneur. @LuciusCaviola

Joe Brewer

Joe is a complexity researcher and a leader in the field of culture design, dedicated to helping humanity make the transition to sustainability. Much of his work has focused on values, identity and modes of thought that shape cultural understandings of political and social issues. He is co-founder and editor of Evonomics magazine, served as research director for TheRules.org, and is coordinator for the newly forming Cultural Evolution Society. @cognitivepolicy

Ethics & values

There is no meaningful ethics without compassion. Compassion means caring about others' suffering and taking concrete actions to relieve it. The focus on "others" is central to ethics, encapsulated in the Golden Rule in all its variations over the millennia: "That which is hateful to you, do not do to your fellow." Compassion is the starting point for any ethical framework and activism that stems from it, with the circle of compassion extending to all sentient beings with the capacity to suffer.
In principle, rationality alone can provide a sufficient argument for being compassionate, because the distinctness of our individual identities is actually an illusion and we are all, in a sense, variations of one other. So from a bird's eye perspective, another one's suffering is equally important to one's own. But in practice, rational argumentation is usually insufficient, and spreading compassion requires that we tap into people's capacity for empathy, raise their awareness of suffering and also encourage them to practice self-compassion.
Ethical philosophy

Ethics is essential for deciding on the principles by which we run our lives and organise ourselves as a society. By combining compassion with rational thinking, we can arrive at a basic ethical framework that gives highest priority to the prevention of intense suffering. It is often unclear what our optimal courses of action should be when so many conflicting opportunities for action exist. Even in theory, it is often impossible to arrive at a definitive conclusion that does not depend at all on our intuitions or on arbitrary decisions. But it is clear that compassion calls us on to strive to eliminate as much intense suffering in the future as possible.

There are many ethical theories in existence, but most of them are arguably flawed by inconsistencies and imprecisions, including the use of numbers in ways that are not rationally justified or that are disconnected from what we actually care about. Nonetheless, ethics must ultimately be about influencing outcomes: about choosing courses of action that have positive impact on the subjective experience of sentient beings.

Ethical theories such as “negative utilitarianism” (NU) that focus on suffering rather than happiness have in the past been overlooked because they seemed to conflict with our intuitions, such as that minor suffering is trivial, or that bringing more happiness into the world is also a good thing. But as individuals, we can personally value the creation of happiness, while still recognising that alleviating intense suffering will always be the ethical priority, because it cannot be cancelled out simply by adding more happiness elsewhere. One shorthand way of formulating this pragmatic ethical philosophy is with the term “xNU+”: “U” stands for utilitarianism - but only in the narrow sense of optimising impact, without aggregating suffering and happiness; “N” stands for negative - that is, focusing on suffering; “x” refers to extreme or intense suffering as our ethical priority, and not minor pains such as pinpricks or the occasional headache; and very importantly, the “+” explicitly acknowledges that human beings have the need and desire to lead happy, meaningful lives, and a workable ethical framework has to allow space for people to thrive, and also accommodate some of their moral intuitions, if they are also to be effective as ethical agents of change.
This approach to ethics shifts the emphasis away from judging individual people as more or less "virtuous", and even from the distraction of labelling specific actions as either "ethical" or "unethical". Ethics is better seen as a continuous process of promoting compassion and rationality, and taking concrete steps to prevent as much future suffering as possible. However, whenever there are decisions to be made about having impact in reducing suffering, all things being equal, we should focus on the most intense suffering and on situations where the greatest number of individuals are affected. More reflections can be found here.

Get Involved

Are you interested in helping to reduce suffering in the world? Although OPIS is not currently hiring staff, we are looking for enthusiastic and creative people willing to contribute some of their time and expertise to projects and campaigns. Specific expertise that would be useful:

  • Teaching and education
  • Fundraising
  • Graphic design
  • Video, film and animation
  • PR and marketing
  • Advocacy and activism

Even if you do not have any of these specific skills or experience, you can collaborate, share your own expertise and help us organise events and campaigns. You can contact us here - please let us know about your background and interests. We look forward to hearing from you!

We are also looking for financial supporters and philanthropists interested in supporting creative new projects and promoting the prevention of intense suffering as our highest global priority. You can donate directly here.


We welcome donations of any size that will help support our organisation and run projects. The Donate button below allows you make a donation via your PayPal account or credit card. We are a Swiss non-profit association, although we do not yet have tax exempt status for Swiss residents. If you have any questions please do not hesitate to contact us.

Donations can also be made directly to:

IBAN: CH17 0900 0000 9116 4774 4
Postfinance Ltd, Mingerstrasse 20, 3030 Berne, Switzerland

If you are considering donating specifically to support our projects to promote morphine access in lower-income countries, this document provides an assessment of the potential effectiveness of donations compared to other cause areas.

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